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Raamat \"Sündmuse toimumise aja lõpp-punktidega kliiniliste uuringute kavandamine ja analüüs\" annab põhjaliku ülevaate selliste kliiniliste uuringute kavandamisest, jälgimisest, analüüsist ja tõlgendamisest, mille puhul sündmuse toimumise aeg on kriitilise tähtsusega.\u003c\/p\u003e  \u003cp\u003ePärast sündmuse toimumise aja lõpp-punkti metoodika, kliiniliste uuringute probleemide ning kliiniliste uuringute kavandamise ja jälgimise ülevaatamist keskendub raamat järeldusanalüüsi meetoditele, sealhulgas parameetrilistele, poolparameetrilistele, kategoorilistele ja Bayesi meetoditele; Coxi mudeli alternatiivile väikeste valimite puhul; ning riski muutuse hindamisele ja testimisele. Seejärel esitatakse kirjeldavad ja graafilised meetodid, mis on kasulikud sündmuse toimumise aja lõpp-punkti analüüsimisel. Järgmistes peatükkides uuritakse mitmesuguseid kliinilisi uuringuid, alates valuvaigistite, antibiootikumide ja viirusevastaste ravimite uuringutest kuni südame-veresoonkonna ja vähi ennetamise, eesnäärmevähi, astrotsütoom-ajukasvaja ja kroonilise müeloidse leukeemia uuringuteni. Seejärel käsitleb raamat ravimite väljatöötamise, meditsiinipraktika ja ohutuse hindamise valdkondi. Lõpetuseks käsitletakse FDA poolt uute ravimitaotluste jaoks nõutavate loomkatsete kliiniliste uuringute kavandamist ja analüüsi.\u003c\/p\u003e  \u003cp\u003eTuginedes ekspertide kogemustele biomeditsiiniliste uuringute ja kliinilise ravimiarenduse alal, hõlmab see põhjalik ressurss mitmesuguseid sündmuse toimumise aja meetodeid ja uurib mitmesuguseid reaalseid rakendusi.\u003c\/p\u003e","brand":"Karl E. 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