{"title":"Nukleotiidid","description":"\u003cp\u003e\u003cstrong\u003eNukleotiidid\u003c\/strong\u003e – sellest kategooriast leiad 13 raamatut. Tunnustatud klassikast uusimate väljaanneteni. Telli internetist, tarnime üle Eesti.\u003c\/p\u003e","products":[{"product_id":"handbook-of-analysis-of-oligonucleotides-and-related-products-9781138198456","title":"Oligonukleotiidide ja nendega seotud toodete analüüsi käsiraamat","description":"\u003cp\u003eOligonukleotiidid on viimaste aastate üks olulisemaid farmaatsiaalaseid läbimurdeid, mis on näidanud üles suurt potentsiaali diagnostiliste ja terapeutiliste ainetena pahaloomuliste kasvajate, südame-veresoonkonna haiguste, diabeedi, viirusnakkuste ja paljude teiste degeneratiivsete haiguste korral. Oligonukleotiidide ja nendega seotud toodete analüüsi käsiraamat on oluline teatmik kaasaegsete ja uudsete analüütiliste meetodite praktilise rakendamise kohta selle ainulaadse ühendite klassi analüüsimisel. Raamat, mis on sündinud kolmekümne maailma juhtiva analüütikuteadlase tugeva koostöö tulemusena, annab lugejatele põhjaliku ülevaate kõige sagedamini kasutatavatest analüütilistest meetoditest ning nende eelistest ja piirangutest terapeutiliseks kasutamiseks mõeldud oligonukleotiidide identiteedi, puhtuse, kvaliteedi ja tugevuse tagamisel.\u003c\/p\u003e\n\u003cp\u003e Aruteluteemade hulka kuuluvad:\u003c\/p\u003e\n\u003cul\u003e\n\u003cp\u003e\u003c\/p\u003e\n\u003cli\u003e Keemiliselt modifitseeritud oligonukleotiidide ensümaatilise või keemilise lagundamise strateegiad massispektromeetrilise sekveneerimise suunas\u003c\/li\u003e  \u003cli\u003ePuhtuse analüüs kromatograafiliste või elektroforeetiliste meetoditega, sealhulgas RP-HPLC, AX-HPLC, HILIC, SEC ja CGE\u003c\/li\u003e\n\u003cli\u003e Oligonukleotiidide järjestusega seotud lisandite iseloomustamine massispektromeetria ja kromatograafia abil\u003c\/li\u003e\n\u003cli\u003e Struktuuri selgitamine spektroskoopiliste meetoditega (IR, NMR, MS) ning aluse koostise ja termilise sulamise analüüs (Tm)\u003c\/li\u003e\n\u003cli\u003e Oligonukleotiidide molaarse ekstinktsioonikordaja täpse määramise lähenemisviisid\u003c\/li\u003e\n\u003cli\u003e Analüüsi väärtuste täpne määramine\u003c\/li\u003e\n\u003cli\u003e Oligonukleotiidide üldise kvaliteedi hindamine, sh mikroobide analüüs ning lahustite ja raskmetallide jääkide määramine\u003c\/li\u003e\n\u003cli\u003e Oligonukleotiidide keemilise stabiilsuse määramise strateegiad\u003c\/li\u003e\n\u003cli\u003e Hübridisatsioonitehnikate kasutamine farmakokineetika ja ravimite metabolismi uuringute toetamiseks prekliinilises ja kliinilises arenduses\u003c\/li\u003e\n\u003cli\u003e Juhised asjakohase analüütilise teabe esitamiseks oligonukleotiidravimite praeguste regulatiivsete ootuste täitmiseks\u003c\/li\u003e\n\u003c\/ul\u003e \u003cp\u003eSee ressurss pakub praktilist juhendit tipptasemel analüütiliste meetodite rakendamiseks teadus-, arendus- ja tootmiskeskkonnas.\u003c\/p\u003e","brand":"Jose V. 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